What is assessed in pre-transplant engraftment testing?

Pre-transplant engraftment testing is primarily focused on the genetic compatibility between the donor and recipient. This is critical for predicting how well the transplanted cells will integrate and function after the procedure. Donor and recipient screening using Short Tandem Repeat (STR) PCR allows for precise analysis of genetic markers, which helps assess the likelihood of successful engraftment and reduces the risk of complications such as graft versus host disease.

This molecular method is particularly beneficial because it can provide a clear genetic fingerprint of both the donor's and recipient's cells. By evaluating these genetic similarities or differences, healthcare professionals can be better informed about the compatibility and optimal match between the two individuals involved in the transplant, leading to more tailored treatment plans and improved outcomes for the patient.