In X-linked recessive disorders, which statement is true regarding males?

In X-linked recessive disorders, males are more frequently affected than females due to the way the X and Y chromosomes are inherited. Males have one X and one Y chromosome (XY), meaning they have only one copy of the gene located on the X chromosome. If that single X chromosome carries a mutation associated with an X-linked recessive disorder, the male will express the disorder because there is no corresponding allele on the Y chromosome that could counteract or mask the defective gene.

Females, on the other hand, have two X chromosomes (XX). Therefore, they can be carriers of the disorder without showing symptoms, as they might inherit one mutated X chromosome and one normal X chromosome. For a female to express an X-linked recessive disorder, she must have two copies of the mutated gene—one on each X chromosome. This genetic dynamic explains why males are more likely to be affected by X-linked recessive conditions.

The other statements are not accurate. Males cannot be carriers of X-linked recessive disorders in the same way females can; they will express the disorder if they inherit the mutated gene. They cannot pass the disorder to their sons, as males pass on their Y chromosome to male offspring. Males may have female offspring that are